Unconjugated Hyperbilirubinemia Gilbert's syndrome defect in glucuronyl transferase 5% of population increase in serum unconjugated bilirubin becomes jaundiced in stressful situations Benign No treatment Crigler-NajjarType I deficiency in glucuronyl transferase markedly increased serum unconjugated bilirubin present in neonates Severe Death from kernicterus by age 1 year Phenobarbitol Crigler-NajjarType II deficiency in glucuronyl transferase increase in serum unconjugated bilirubin Mild Patients suffer from no severe clinical deficits Phenobarbitol Conjugated Hyperbilirubinemia Dubin-Johnson syndrome defective bilirubin excretion increase in serum conjugated bilirubin presents with jaundice Benign No treatment Liver turns black Rotor syndrome defective bilirubin storage increase in serum conjugated bilirubin presents with jaundice Benign No treatment