Introduction Most common congenital infection TORCH infection (Toxoplasmosis, Other [Syphilis], Rubella, CMV, and Herpes) Transmitted via body fluids including respiratory droplet blood transfusion sexual contact breast milk Epidemiology 70% of adults in the United States have been infected transmission occurs in 1% of all births 10% of infected infants manifest congenital defects of varying severity 10% of asymptomatic but infected infants develop neurologic sequelae later See Infectious Diseases, Cytomegalovirus (CMV)