Introduction Oral lesion caused by squamous hyperplasia Associated with ↑ risk of oral squamous cancer May also be red (erythroplakia) Most commonly seen at the vermilion border of lower lip can be seen anywhere in the mouth Cause alcohol tobacco use infection (EBV, HPV) chronic irritation (e.g. poor-fitting dentures) Presentation Physical exam lesion cannot be scraped off Evaluation Biopsy must assess for oral cancer risk