Somatropin Growth hormone (GH) mimetic Mechanism agonist at GH receptors increases production of insulin growth factor-1 (IGF-1) Clinical use GH deficiency increase adult height in children in conditions associated with short stature Turner's syndrome wasting in HIV infection short bowel syndrome Toxicity scoliosis edema gynecomastia increased CYP450 activity Octreotide Somatostatin mimetic Mechanism agonist at somatostatin receptors Clinical use acromegaly carcinoid gastrinoma glucagonoma acute esophageal variceal bleed Toxicity GI upset gallstones bradycardia Oxytocin Mechanism agonist at oxytocin receptor Clinical use stimulation of labor uterine contractions control of uterine hemorrhage after delivery stimulate milk letdown Toxicity fetal distress abruptio placentae uterine rupture Desmopressin ADH (vasopressin) mimetic Mechanism agonist at vasopressin V2 receptors Clinical use central (pituitary) diabetes insipidus hemophilia A von Willebrand disease Toxicity GI upset headache hyponatremia allergic reaction Leuprolide GnRH rmimetic Clinical use idiopathic central precocious puberty