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Updated: Dec 7 2015

Sheehan's Syndrome

Snap Shot
  • 5 days post-vaginal delivery, a 26-year-old woman presents to her pediatrician with the inability to breast feed her child. History reveals that her vaginal delivery was complicated by a postpartum hemomorhage.
Introduction
  • Postpartum hemmorhage-induced infarction of the pituitary gland
    • result of hypovolemic shock
      • pituitary normally very enlarged during pregancy due increased lactotrophs
      • there is no corresponding increase in blood supply to the pituitary gland and can infarct when systemic blood pressure drops
    • hypopituitarism results in reduced prolactin secretion
  • Mecahism
Presentation
  •  Symptoms 
    • sudden cessation of lactation or failure to commence lactation
      • loss of prolactin
    • fatigue
      • loss of TSH
    • loss of pubic and axillary hair
      • loss of LH/FSH
    • anorexia
Evaluation
  • Only clinically significant cause of lower than normal serum prolactin levels
  • Imaging
    • MR
      • shows infarction of the pituitary gland
Question
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