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Updated: May 31 2016

Paraneoplastic Effects of Tumors

Overview
Neoplasm
Potential Tumor Products
Presenation
Small cell lung carcinoma ACTH, ADH, Antibodies against presynaptic Ca2+ channels at neuromuscular junction Cushing's syndrome, SIADH , Lambert-Eaton syndrome
Squamous cell lung carcinoma PTH-related peptide, TGF-β, TNF, IL-1 Hypercalcemia
Renal cell carcinoma Erythropoietin
Polycythemia, Hypercalcemia
Thymoma Antibodies against nicotinic acetylcholine receptors at the postsynaptic neuromuscular junction Myasthenia gravis
Hemangioblastoma Erythropoietin Polycythemia
Intracranial neoplasm ADH SIADH
Breast carcinoma PTH-related peptide, TGF-β, TNF, IL-1 Hypercalcemia
Leukemias and lymphomas Excess nucleic acid turnover Gout, urate nephropathy
Question
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Private Note

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