Snapshot A 7-year-old boy presents to the pediatrician with complaints of a fever, sore throat, rhinorrhea, and red eyes. Physical exam revealed a non-exudative pharyngitis and pre-auricular lymphadenopathy. Introduction Classification virus DNA virus double-stranded and linear non-enveloped adenovirus Common, usually febrile illness that can affect many different body systems Disease conditions acute febrile pharyngitis pharyngoconjunctival fever acute respiratiory disease conjunctivitis gastroenteritis Mechanism infection of mucoepithelial cells of the respiratory tract (most common) GI tract conjunctiva cornea causes direct cell damage Transmitted by body fluids including respiratory droplet fecal-oral close contact Associated conditions intussusception and volvulus - abdominal emergency in early childhood Presentation Symptoms general low grade fever malaise chest congestion eye hyperemia conjunctivitis blepharitis lung pneumonia croup bronchitis GI nausea vomiting diarrhea abdominal pain Physical exam manifestations of disease range across organ systems pharyngitis shotty lymphadenopathy rhinorrhea nasal congestion diffuse abdominal pain hyperactive bowel sounds corneal injection Evaluation Viral culture slow but may isolate pathogen PCR fast way to identify adenoviral pathogen Differential For the most common presentation see Pharyngitis Treatment Most are mild and do not necessitate treatment Symptomatic NSAIDs or acetominophen for fever hydration There are no antiviral medications specific for adenoviral infections Prognosis, Prevention, and Complications Prevention vaccination in high-risk groups live oral enteric-coated vaccine given to military recruits infection control procedures contact and droplet precaution chlorination of swimming pools