Overview Drugs filgrastim granulocyte colony-stimulating factor (G-CSF) sargramostim granulocyte-macrophage colony-stimulating factor (GM-CSF) Mechanism stimulate production and function of neutrophils stimulate other myeloid and megakaryocyte progenitors (sargramostim only) increase concentration of hematopoietic stem cells in the peripheral blood (filgrastim > sargramostim) Clinical use neutropenia cancer chemotherapy aplastic anemia congenital neutropenia stem cell transplantation Toxicity filgrastim minimal bone pain sargramostim fever arthralgias edema