Misoprostol Mechanism PGE1 analog ↑ production and secretion of HCO3- and mucus in mucous barrier ↓ HCl secretion Clinical use treatment/prevention of NSAID-induced peptic ulcers maintenance of a patent ductus arteriosus in congential heart abnormalities abortifacient/labor induction Toxicity diarrhea abortifacient action in women